Vegetation cover changes in Guanzhong Plain in 1999-2010 were analyzed by using SPOT NDVI data. Maximum value composites, mean value analysis and linear regression analysis were used to characterize the vegetation cover change in Guanzhong Plain, and the data of the yearly-averaged temperature and annual precipitation were employed to deduce the correlation coefficient between Normalized Difference Vegetation Index (NDVI) and temperature /precipitation based on correlation analysis. The results suggest that the situation of vegetation cover is good in most region of Guanzhong Plain, the value of NDVI is highest in the northern slope of Qingling Mountain and lowest in urban; In general, the yearly mean NDVI increased over 1999 to 2010 at a rate of 5%/10a. The proportion of slight increased areas is 70.39%, 24.77% is keeping stable basically which show that the vegetation cover in Guanzhong Plain had been steady rising; The response of the changing NDVI to temperature /precipitation is good, positive correlation between NDVI and temperature /precipitation in most of the region is found.