Abstract: Intestinal growth is the core the core and base of pig lets development and rapid growth. The intestine of newborn piglets is insufficiently developed. And weaning stress induces marked morphological and functional changes in the intestine, and generally results in villus atrophy, increased transepithelialperme ability, decreased digestive and absorptive capacity and impaired intestinal barrier. Amino acids are nutrients utilized preferentially by intestine. Amino acids enter intestinal epithelial cells via transporters and act on the corresponding receptors, activating cell signaling and regulating intracellular physiological processes. As major energy sources for mucosa and precursors for protein and some signaling molecules synthesis, amino acids play important roles in intestinal growth and development, as well as the maintains of structure and function. Focusing on the intestinal development and amino acids utilization in piglets, this article will reveal the laws of development of mucosal morphology and adaptive change after weaning, clarify the mechanisms of amino acid sensing and utilization as well as the regulation of amino acids on development of intestinal structure and function. It will provide a theoretical basis for the regulation of intestinal amino acid metabolism and improvement of dietary amino acids utilization and has important scientific significance to improve the intestinal health and production efficiency in piglets.