Abstract: Land use is the carrier of the development of leisure tourism in tourism cities. The study on the land use change and it’s interaction with leisure tourism in tourism city has important theoretical value and practical significance in optimizing the land use pattern and enhancing the comprehensive benefits of leisure tourism development. Taking Zhangjiajie, Hunan Province, a typical tourist city, as example, and applying the RS and GIS technology, this paper analyzed the dynamic change of land use structure in Zhangjiajie, and examined the relationship between the land use change and the development of leisure tourism. Results show that, from the perspective of the dynamic degree of land use, the pattern of land use in Zhangjiajie has changed a lot and construction land has grown quickly; while woodland, grassland and arable land were still the three main types of land use over the past 20 years. From the perspective of transformation in land use pattern, the main type is from cultivated land and grassland into leisure tourism construction land and forest land. Therefore, this study reveals that there is an interaction between land use change and leisure tourism development in Zhangjiajie City, and it is mainly manifested in a transformation from agricultural land and industrial land into tourism construction land. While leisure tourism development restricts the transformation land from cultivated land to tourism construction land at the same time. The change of urban land use not only plays a strong leading role in the development of leisure tourism, but also has important influences on the change of land use. In conclusion, it is necessary for Zhangjiajie City to ensure land needs of urban infrastructure construction, leisure industry development and ecology construction in future leisure tourism development and to provide strong support for the rational distribution of tourism industry element and the construction of eco-tourism city.