Abstract: Karst waterlogging is a distinct disaster in karst area, which closely relates with karst eco-environment and human activities in subtropical wet climate. The karst waterlogging area of Guangxi are mainly distributed in four landforms such as peak-cluster depression, peak-cluster valley, karst plains, and the transitional zone between karst and non-karst areas. And peak-cluster depression region is the most frequency and largest area of karst waterlogging. Two-dimensional hydrology, precipitation, and human disturbance are the principal factors of karst waterlogging in peak-cluster depression. The universal measures combined with prevention and comprehensive control should be adopted, which was decided by the classification and distribution of karst waterloggin in peak-cluster depression, characteristics of terra and topography, distribution of residents and croplands, the investment efficiency of project, and the causes of waterlongging. Moreover, pertinent irrigation and ecological practices should be done in the most serious waterlogging areas of low cluster-peak depression and high cluster-peak depression. All these countermeasures of karst waterlogging would be a guarantee of the sustainable ecology and economic development in the area.