Abstract: In order to explore the distribution pattern of the main soil chemical properties in a small catchment in Karst peak-cluster depression area, the spatial heterogeneity of soil nutrients (TN, TP, TK, AN, AP, AK, SOM, pH) in surface soil (0cm~20cm) were studied by the methods of classical statistics and geostatistics. The total 163GPS- referenced soil samples were collected with grid sampling plots (80m × 80m) in Huanjiang Observation and Research Station of Karst Ecosystem in a small catchment in Karst peak-cluster depression area. The results showed that the differences of the contents of the eight soil nutrient components were large; the variance coefficients of all the eight soil nutrient components were large with the order of TK (total potassium) > AP (available phosphorus) >AN (available nitrogen) > TN (total nitrogen) > SOM (soil organic matter) > AK (available potassium) > TP (total phosphorus) > pH. The spatial patterns and the fittest models of the eight soil nutrient components were quite different from each other. All soil nutrient components had medium spatial autocorrelation with long range and well spatial continuum except TK and pH which had strong spatial autocorrelation with short ranges. The Kriging contour maps indicated that, the distribution pattern of TN, AN, SOM and pH were similar, but pH showed an opposite trend in space with others. In addition, similar patterns were also recognized between TP and AP, and between TK and AK. As a whole, expect pH, all the soil nutrient contents were higher in south and east,lower in north and west, higher in depression, lower in slope. The results indicated that human disturbance and nature condition (the topography, the landform, the slope, the exposure, the bare rock rate, the vegetation, etc.) were the most important factors to affect the spatial patterns of soil nutrients in small catchment in Karst peak-cluster depression region.