Abstract: Based on the economic development statistics of Hubei Province in 2009, the essay has comprehensively analyzed the space characteristic of county regional economic development in Hubei Province by using Principal Component Analysis and Spatial Autocorrelation Analysis method. The result shows that the county regional economy in Hubei Province appears to have“dual-nuclei structure”,“pyramid structure”,“the circle structure”, and“pole-axis spatial”characteristics. The developed counties (the first and second circle) are around“Yichang City and Wuhan City” as well as along the Yangtze River, Shanghai- Chengdu expressway, Beijing- Guangzhou, Beijing- jowloon, Jiaozhi railway; the third circle is located in the central and eastern of Jianghan plain, and the fourth circle is located in the edge of the province. From the point view of the space, the county regional economy has“high - high”concentration, but lacks in obvious“low - low”concentration. There are four types of development, including concentration development, pole- nuclei development and equilibrium development, edge development. According to the analysis, this paper puts forward the space optimal path of county regional economy in Hubei Province, which suggests to construct the Wuhan - Jingzhou megalopolis, make Yichang and Xiangfan city to be the urban growth poles, strengthen the“two-axis fourwire” and accelerate the comprehensive development of the county in western Hubei Province