Abstract: The Agro-product Geographical Indication Brands(AGIB) plays a critical role in promoting the structural reform of the agricultural industry and implementing the strategy of rural revitalization. A large body of literature has focused on protecting intellectual property rights of the AGIB, extracting its economic value, and improving its competitiveness. However, inadequate attention has been paid to the spatial attributes of the AGIB. Therefore, this paper seeks to investigate the spatial heterogeneity of the AGIB and its influencing factors by a mixture of spatial analysis, geographic detector, and qualitative analysis methods based on the Agro-product Geographical Indicator (AGI), Geographical Indicator (GI), and the Protected Geographical Indicator (PGI). Results show that 86.28% of the AGIB are distributed in the east of the Hu line and concentrated in the coastal areas and the Yangtze River Basin, which tends to overlap the T-shaped economic belt. The density of the AGIB shows significant spatial autocorrelation. The central and downstream areas of the Yangtze River are hot spots, such as Hubei, Jiangsu, Anhui, Zhejiang, and Shanghai, whereas areas in Western China are cold spots (Xinjiang, Qinghai, and Tibet). In addition, the spatial distribution of the AGIB, such as vegetables, oils, and fruits, demonstrates a pattern which are adapt to the environment. Moreover, the heterogeneity of AGIB is affected by the social environment, natural environment, and local governance. The possible reason for this might be the interaction between the secondary industry and the railway density. Therefore, based on the analysis results, this paper provides some policy suggestions for regional cooperation of agricultural brand construction, spatial allocation of resource elements, and brand protection techniques to promote the progress of the Rural Revitalization and agricultural brand strategy.