Abstract: Veterinary drug plays a critical role in hot farming. However, improper use may result in residues of veterinary drugs in pork and further cause the spread of drug-resistant bacteria in the food chain system, posing a potential risk to human health. Based the survey data from 654 hot farms in Funing, Jiangsu Province and the earnings expectation theory, applying Multivariate Probit(MVP) model, this paper examined the influencing factors of hog farmers’ behaviors when applying veterinary drugs. Results show that 1) the behaviors of excessive application of veterinary drugs and non-compliance with the withdrawal period are common in hog farming; 2) the non-compliance farms with withdrawal period accounting for about 70% of the samples; 3) farmers’ gender, age, family size, the proportion of farming income in total net income, farming scale, breeding period, sales target, awareness of veterinary drug residues and understanding of the government penalties for non-compliance have significant influence on their behaviors; and 4) government regulation has a significant influence on the behavior of using human drug in hog farming, while not on the behavior of the excessive use of veterinary drugs and non-compliance with the withdrawal period.